What is the half-life of heparin?

The half-life of heparin typically ranges from approximately 1 to 2 hours, with an average around 1.5 hours. This measurement represents the time it takes for the concentration of heparin in the bloodstream to reduce by half. It is important to understand this pharmacokinetic parameter when administering heparin, as it influences the dosing schedule and the timing of monitoring for therapeutic effects or potential adverse reactions.

In clinical settings, factors such as the patient's individual metabolism, the type of heparin administered (unfractionated vs. low molecular weight heparin), and the presence of renal impairment can affect the half-life, but the general understanding remains that it is close to 1.5 hours under normal circumstances. Therefore, the choice reflecting this time frame is deemed accurate in the context of heparin's pharmacology.